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Body in Tune: Music and the Immune System

article by Sync Project’s 

Stress is everywhere. From paying bills on time to meeting important deadlines at work – acceptable stress levels motivate you to get tasks done. But too much stress – and for too long – can lead to detrimental health effects, both mental and physical. In this post, we’ll explore the effect of stress on the immune system and how music can reduce the impact of unhealthy stress on the immune system.

Cortisol and epinephrine (also called adrenaline), two key hormones released when encountered with stressful stimuli (also know as stressors), are particularly well-known for their roles in “Fight or Flight” response. The “Fight or Flight” response, an evolutionary trait used in times of peril, is mediated by these hormones, which prime the body for combat or quick escape. Our early ancestors used the “fight or flight” response to aid in life or death situations regularly, such as encountering predators or natural disaster. Despite drastic lifestyle changes since this primitive era, our stress-response system is still a commonly engaged in modern society. We may not need to worry about getting mauled by a bear in the middle of town, but we do tend to fret over things such as work, exams, and the fast-paced nature of everyday life.

Although normal surges of cortisol are helpful in going about one’s day, excessive and prolonged levels of cortisol can lead to adverse health effects. A major health risk of high cortisol levels is the potential for immune system suppression. Short bursts of stress (also known as acute stress), like giving a public speech, can actually temporarily boost the immune system. If short bursts of stress become a more long-term problem however, this may be diagnosed as chronic stress. Chronic stress can lead to a decrease in immune system function, which contributes increased disease vulnerability. Lengthy periods of stress can increase the chance of developing illnesses and can even increase the time for the body to recover from a disease. In this article, we’ll look at how music can alleviate stress, making music a simple and easy way to stave off stress-induced immune suppression.

In studies that investigated the correlation between stress and illness, results showed that people with higher stress levels tended to be more susceptible to developing disease. Research focused on diseases like Epstein-Barr virus (Mono) and Herpes zoster (Shingles), which lie dormant before the disease develops and symptoms become prevalent. A case-control study demonstrated that high stress levels were correlated with an increased chance of retriggering the inactive varicella-zoster virus, which causes shingles. In an Epstein-Barr study, West Point Academy cadets who were under heavy social/academic pressure were more likely to contract the disease, and were also more likely to be hospitalized for longer periods than those who were less stressed; the study also showed that stress also increased the likelihood of relapsing during recovery.

Research on the immune system shows many functions of the immune system are weakened and reduced in an environment which induces chronic stress. For example, in caregivers for spouses with dementia, greater chronic stress and emotional anguish reduced the immune system response to influenza-virus vaccine (aka the common flu), a response necessary for the body to become immune to the disease.

The study results indicate dementia can lead to negative health effects in caregivers, reducing their immune systems’ efficiency and making them more susceptible to illness. In previous posts, we’ve shown how music can alleviate the symptoms of dementia and Alzheimer’s – music could also potentially help the caregivers reduce stress and boost their immune system.

Studies have also examined the negative role of stress in immune function in non-clinical groups, like students studying for tests and exams. One study showed how a mouth injury healed 40% more slowly during exam times for students than when they were on summer break. Research shows that when introduced to chronic stress, multiple roles of the immune system are compromised, leading to adverse health effects.

Research on the immune system shows many functions of the immune system are weakened and reduced in an environment which induces chronic stress. For example, in caregivers for spouses with dementia, greater chronic stress and emotional anguish reduced the immune system response to influenza-virus vaccine (aka the common flu), a response necessary for the body to become immune to the disease.

The study results indicate dementia can lead to negative health effects in caregivers, reducing their immune systems’ efficiency and making them more susceptible to illness. In previous posts, we’ve shown how music can alleviate the symptoms of dementia and Alzheimer’s – music could also potentially help the caregivers reduce stress and boost their immune system.

Studies have also examined the negative role of stress in immune function in non-clinical groups, like students studying for tests and exams. One study showed how a mouth injury healed 40% more slowly during exam times for students than when they were on summer break. Research shows that when introduced to chronic stress, multiple roles of the immune system are compromised, leading to adverse health effects.

 

 

*This article was reprinted with the permission of Sync Project.

About Sync Project

Developing music as precision medicine

Intuitively we know the power that music has over us. We all self-medicate with music. Recent research has shown that music affects the same neural pathways that are regulated by psychostimulants and other drugs.

Sync Project is building on this foundation and partnering with the world’s leading scientists and musicians on the first-ever large-scale studies to measure how the structural properties of music – like beat, key and timbre – impact biometrics such as heart rate, brain activity and sleep patterns. Sync Project is applying machine learning to this dataset to develop personalized music therapeutics.

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